Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE)
Identifieur interne : 001995 ( Main/Exploration ); précédent : 001994; suivant : 001996Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE)
Auteurs : Kunihiko Nagasato [États-Unis] ; R. Wesley Farris Ii [États-Unis] ; Monique Dubois-Dalcq [États-Unis] ; Rhonda R. Voskuhl [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1997.
English descriptors
- KwdEn :
- Teeft :
- Adjacent sections, Adoptive transfer, Adult mice, Antisense sequence, Chronic relapsing, Clinical disease, Clinical score, Cryostat sections, Current address, Demyelinating disease, Demyelination, Developmental myelination, Disease stage, Encephalomyelitis, Episode peak recovery, Exon, First episode, Grain clusters, Hybridization, Inflammatory infiltrates, Kunihiko nagasato, Lesion, Lymph node cells, Molecular marker, Multiple sclerosis, Myelin, Myelin gene transcripts, Myelin sheaths, Oligodendrocyte, Passive transfer, Preclinical stage, Proteolipid protein, Raine, Recovery stage, Relapsing, Remyelinating oligodendrocytes, Remyelination, Sclerosis, Second episode, Sense probe, Sjlrj mice, Specific clusters, Spinal, Spinal cord, Spinal cord lesions, Spinal cord sections, Spinal cords, Transcript, Transcript expression, Transcripts coding.
Abstract
Abstract: Exon 2 containing myelin basic protein (MBP) transcripts are expressed during developmental myelination in mice and humans, and during remyelination subsequent to virally induced demyelination in adult mice. Since remyelination characterizes CNS lesions during experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS), we investigated whether exon 2 containing isoforms of MBP are expressed in EAE lesions during relapsing disease. Exon 2 containing MBP transcripts were detected by in situ hybridization in 17 of 52 EAE mice and in 16 of 30 mice at the peak of the first or second episode of paralysis. Thus exon 2 containing MBP transcripts are expressed in lesions of the CNS during active phases of chronic relapsing autoimmune disease. Implications of these findings with respect to future therapies aimed toward enhancing remyelination in EAE and, possibly MS, are discussed.
Url:
DOI: 10.1016/S0165-5728(96)00137-3
Affiliations:
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Voskuhl</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Viral and Molecular Pathogenesis, NINDS, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="21">21</biblScope><biblScope unit="page" to="25">25</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Experimental allergic encephalomyelitis</term><term>Multiple sclerosis</term><term>Myelin basic protein</term><term>Remyelination</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adjacent sections</term><term>Adoptive transfer</term><term>Adult mice</term><term>Antisense sequence</term><term>Chronic relapsing</term><term>Clinical disease</term><term>Clinical score</term><term>Cryostat sections</term><term>Current address</term><term>Demyelinating disease</term><term>Demyelination</term><term>Developmental myelination</term><term>Disease stage</term><term>Encephalomyelitis</term><term>Episode peak recovery</term><term>Exon</term><term>First episode</term><term>Grain clusters</term><term>Hybridization</term><term>Inflammatory infiltrates</term><term>Kunihiko nagasato</term><term>Lesion</term><term>Lymph node cells</term><term>Molecular marker</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin gene transcripts</term><term>Myelin sheaths</term><term>Oligodendrocyte</term><term>Passive transfer</term><term>Preclinical stage</term><term>Proteolipid protein</term><term>Raine</term><term>Recovery stage</term><term>Relapsing</term><term>Remyelinating oligodendrocytes</term><term>Remyelination</term><term>Sclerosis</term><term>Second episode</term><term>Sense probe</term><term>Sjlrj mice</term><term>Specific clusters</term><term>Spinal</term><term>Spinal cord</term><term>Spinal cord lesions</term><term>Spinal cord sections</term><term>Spinal cords</term><term>Transcript</term><term>Transcript expression</term><term>Transcripts coding</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Exon 2 containing myelin basic protein (MBP) transcripts are expressed during developmental myelination in mice and humans, and during remyelination subsequent to virally induced demyelination in adult mice. Since remyelination characterizes CNS lesions during experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS), we investigated whether exon 2 containing isoforms of MBP are expressed in EAE lesions during relapsing disease. Exon 2 containing MBP transcripts were detected by in situ hybridization in 17 of 52 EAE mice and in 16 of 30 mice at the peak of the first or second episode of paralysis. Thus exon 2 containing MBP transcripts are expressed in lesions of the CNS during active phases of chronic relapsing autoimmune disease. Implications of these findings with respect to future therapies aimed toward enhancing remyelination in EAE and, possibly MS, are discussed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Nagasato, Kunihiko" sort="Nagasato, Kunihiko" uniqKey="Nagasato K" first="Kunihiko" last="Nagasato">Kunihiko Nagasato</name></region><name sortKey="Dubois Dalcq, Monique" sort="Dubois Dalcq, Monique" uniqKey="Dubois Dalcq M" first="Monique" last="Dubois-Dalcq">Monique Dubois-Dalcq</name><name sortKey="Farris Ii, R Wesley" sort="Farris Ii, R Wesley" uniqKey="Farris Ii R" first="R. Wesley" last="Farris Ii">R. Wesley Farris Ii</name><name sortKey="Voskuhl, Rhonda R" sort="Voskuhl, Rhonda R" uniqKey="Voskuhl R" first="Rhonda R." last="Voskuhl">Rhonda R. Voskuhl</name><name sortKey="Voskuhl, Rhonda R" sort="Voskuhl, Rhonda R" uniqKey="Voskuhl R" first="Rhonda R." last="Voskuhl">Rhonda R. Voskuhl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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